| 题名: | A/C polymorphism in the interleukin-18 coding region among Taiwanese systemic lupus erythematosus patients |
| 作者: | Ying-Ju Lin;Lei Wan;Jim Jinn-Chyuan Sheu;Chung-Ming Huang;Cheng-Wen Lin;Yu-Ching Lan;Chih-Ho Lai;Chien-Hui Hung;Yuhsin Tsai,;Chang-Hai Tsai;T-H Lin;Chih-Ping Chen;Fuu-Jen Tsai |
| 贡献者: | 生醫所 |
| 日期: | 2008-02-01 |
| 上传时间: | 2015-03-16 15:40:37 (UTC+8) |
| 摘要: | Interleukin-18 (IL-18) is associated with chronic inflammation, autoimmune diseases and various cancers and infectious diseases. An IL-18 genetic A/C polymorphism at coding position 105 (rs549908) has been linked with asthma and rheumatoid arthritis. We tested a hypothesis that the IL-18 genetic polymorphism confers systemic lupus erythematosus (SLE) susceptibility. Study participants were Taiwanese SLE patients and a healthy control group. Our results indicate (1) a significantly higher A allele frequency in SLE patients (P = 0.003; OR = 1.97; 95% CI = 1.26—3.08) and (2) a significantly higher A allele frequency in SLE patients with a central nervous system disorder (P = 0.027; OR = 7.18; 95% CI = 0.95—54.28). Our results suggest that the A/C polymorphism contributes to SLE pathogenesis. Lupus (2008) 17, 124—127. |
| 關聯: | Lupus, 17(2), 124-127. doi:10.1177/0961203307086031
https://doi.org/10.1177/0961203307086031 |
| 显示于类别: | [生物醫學研究所] 期刊論文
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