Stem Cell-Based Therapy in Neural Repair

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题名:	Stem Cell-Based Therapy in Neural Repair
作者:	Yi-Chao Hsu;Su-Liang Chen;Dan-Yen Wang;Ing-Ming Chiu1
贡献者:	生醫所
关键词:	cell therapy;fibroblast growth factor 1;induced neurons;neural stem cells;neuroregeneration;peripheral nerve injury
日期:	2013-05-01
上传时间:	2015-03-16 15:47:14 (UTC+8)
摘要:	Cell-based therapy could aid in alleviating symptoms or even reversing the progression of neurodegenerative diseases and nerve injuries. Fibroblast growth factor 1 (FGF1) has been shown to maintain the survival of neurons and induce neurite outgrowth. Accumulating evidence suggests that combination of FGF1 and cell-based therapy is promising for future therapeutic application. Neural stem cells (NSCs), with the characteristics of self-renewal and multipotency, can be isolated from embryonic stem cells, embryonic ectoderm, and developing or adult brain tissues. For NSC clinical application, several critical problems remain to be resolved: (1) the source of NSCs should be personalized; (2) the isolation methods and protocols of human NSCs should be standardized; (3) the clinical efficacy of NSC transplants must be evaluated in more adequate animal models; and (4) the mechanism of intrinsic brain repair needs to be better characterized. In addition, the ideal imaging technique for tracking NSCs would be safe and yield high temporal and spatial resolution, good sensitivity and specificity. Here, we discuss recent progress and future development of cell-based therapy, such as NSCs, induced pluripotent stem cells, and induced neurons, in neurodegenerative diseases and peripheral nerve injuries.
關聯:	Biomedical Journal, 36(3), 98-105. https://doi.org/10.4103/2319-4170.113226
显示于类别:	[生物醫學研究所] 期刊論文

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