Stem Cell-Based Therapy in Neural Repair

請使用永久網址來引用或連結此文件: http://140.112.115.32:8080/ir/handle/987654321/1500

題名:	Stem Cell-Based Therapy in Neural Repair
作者:	Yi-Chao Hsu;Su-Liang Chen;Dan-Yen Wang;Ing-Ming Chiu1
貢獻者:	生醫所
關鍵詞:	cell therapy;fibroblast growth factor 1;induced neurons;neural stem cells;neuroregeneration;peripheral nerve injury
日期:	2013-05-01
上傳時間:	2015-03-16 15:47:14 (UTC+8)
摘要:	Cell-based therapy could aid in alleviating symptoms or even reversing the progression of neurodegenerative diseases and nerve injuries. Fibroblast growth factor 1 (FGF1) has been shown to maintain the survival of neurons and induce neurite outgrowth. Accumulating evidence suggests that combination of FGF1 and cell-based therapy is promising for future therapeutic application. Neural stem cells (NSCs), with the characteristics of self-renewal and multipotency, can be isolated from embryonic stem cells, embryonic ectoderm, and developing or adult brain tissues. For NSC clinical application, several critical problems remain to be resolved: (1) the source of NSCs should be personalized; (2) the isolation methods and protocols of human NSCs should be standardized; (3) the clinical efficacy of NSC transplants must be evaluated in more adequate animal models; and (4) the mechanism of intrinsic brain repair needs to be better characterized. In addition, the ideal imaging technique for tracking NSCs would be safe and yield high temporal and spatial resolution, good sensitivity and specificity. Here, we discuss recent progress and future development of cell-based therapy, such as NSCs, induced pluripotent stem cells, and induced neurons, in neurodegenerative diseases and peripheral nerve injuries.
關聯:	Biomedical Journal, 36(3), 98-105. https://doi.org/10.4103/2319-4170.113226
顯示於類別:	[生物醫學研究所] 期刊論文

文件中的檔案:

檔案	描述	大小	格式	瀏覽次數
index.html		0Kb	HTML	11	檢視/開啟

在MMCIR中所有的資料項目都受到原著作權保護.

資料載入中.....