The -590 C/T and 8375 A/G interleukin-4 polymorphisms are not associated with Kawasaki disease in Taiwanese children.

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题名:	The -590 C/T and 8375 A/G interleukin-4 polymorphisms are not associated with Kawasaki disease in Taiwanese children.
作者:	Fu-Yuan Huang;Tzu-Yang Chang;Ming-Ren Chen;Hung-Chang Lee;Nan-Chang Chiu;Hsin Chi;Chyong-Hsin Hsu;Shuan-Pei Lin;Hsin-Fu Liu;Wei-Fang Chen;Chen-Chung Chu;Marie Lin;Yann-Jinn Lee
贡献者:	生醫所
日期:	2008-01-01
上传时间:	2015-03-16 15:47:47 (UTC+8)
摘要:	Although some previous studies have reported that genetic and immunologic factors play important roles in the pathogenesis of Kawasaki disease (KD), the etiologic factors of this enigmatical pediatric disease are still poorly understood. This study aims to investigate whether polymorphisms of the interleukin-4 gene (IL-4; −590 C/T in the promoter region and 8375 A/G in intron 3) are associated with KD and the development of coronary artery lesions (CALs) in Taiwanese children. Genomic DNA was extracted from whole-blood samples from 150 children with KD and 472 ethnically matched healthy control subjects. The IL-4 −590 C/T and 8375 A/G single nucleotide polymorphisms (SNPs) were genotyped by a real-time polymerase chain reaction system with the Pre-Developed TaqMan Allelic Discrimination Assay. No significant associations between IL-4 SNPs and susceptibility of KD with CALs were found. In addition, no evidence for associations between IL-4 SNPs and CAL development was found. These results suggest that IL-4 −590 C/T and 8375 A/G SNPs do not confer a relevant role in the susceptibility or CAL development of KD in Taiwanese children.
關聯:	Human Immunology, 69(1), 52-57. doi:10.1016/j.humimm.2007.11.002 https://doi.org/10.1016/j.humimm.2007.11.002
显示于类别:	[生物醫學研究所] 期刊論文

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