4-Acetylantroquinonol B Suppresses Tumor Growth and Metastasis of Hepatoma Cells via Blockade of Translation-Dependent Signaling Pathway and VEGF Production

doi:10.1021/jf504434v

Please use this identifier to cite or link to this item: http://140.112.115.32:8080/ir/handle/987654321/1900

Title:	4-Acetylantroquinonol B Suppresses Tumor Growth and Metastasis of Hepatoma Cells via Blockade of Translation-Dependent Signaling Pathway and VEGF Production
Authors:	Chien-Hsin Chang;Tur-Fu Huang;Kung-Tin Lin;Chun-Chieh Hsu;Wei-Luen Chang;Shih-Wei Wang;Feng-Nien Ko;Hui-Chin Peng;Ching-Hu Chung;Feng-Nien Ko;Hui-Chin Peng;Ching-Hu Chung
Contributors:	醫學系
Keywords:	hepatocellular carcinoma;Antrodia cinnamomea;4AAQB;RhoGTPase;mTOR;metastasis;VEGF
Date:	2014-12-01
Issue Date:	2015-07-01 13:40:10 (UTC+8)
Abstract:	Hepatocellular carcinoma (HCC) has become one of most common malignancies and a leading cause of cancer mortality worldwide. Previous study has shown that 4-acetylantroquinonol B (4AAQB) isolated from Antrodia cinnamomea (or niu-chang-chih) was observed to inhibit HepG2 cell proliferation via affecting cell cycle. However, the in vivo effects and antimetastatic activity of 4AAQB have not yet been addressed. This study found that 4AAQB inhibited HepG2 and HuH-7 hepatoma cell growth in both in vitro and in vivo models and exhibited pronounced inhibitory effects on HuH-7 tumor growth in xenograft and orthotopic models. 4AAQB efficiently inhibited the phosphorylation of mTOR and its upstream kinases and the downstream effectors and decreased the production of VEGF and activity of Rho GTPases in HuH-7 cells. Furthermore, 4AAQB inhibited in vitro HuH-7 cell migration and in vivo pulmonary metastasis. The results suggested that 4AAQB is a potential candidate for HCC therapy.
Relation:	Journal of Agricultural and Food Chemistry, 63(1), 208–215. https://doi.org/10.1021/jf504434v
Appears in Collections:	[School of Medical] Journal

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