馬偕醫學大學機構典藏(MacKay Medical University Institutional Repository):

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	Prevention of arterial thrombosis b...
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2014-04-01

Amarogentin, a Secoiridoid Glycoside, Abrogates Platelet Activation through PLCγ2-PKC and MAPK Pathways

Ting-Lin Yen; Wan-Jung Lu; Li-Ming Lien; Philip Aloysius Thomas; Tzu-Yin Lee; Hou-Chang Chiu; Joen-Rong Sheu; Kuan-Hung Lin

2014-07-01

Andrographolide induces vascular smooth muscle cell apoptosis through a SHP-1-PP2A-p38MAPK-p53 cascade

Yu-Ying Chen; Cheng-Ying Hsieh; Thanasekaran Jayakumar; Kuan-Hung Lin; Duen-Suey Chou; Wan-Jung Lu; Ming-Jen Hsu; Joen-Rong Sheu

2016-04-01

Andrographolide stimulates p38 mitogen-activated protein kinase–nuclear factor erythroid-2-related factor 2–heme oxygenase 1 signaling in primary cerebral endothelial cells for definite protection against ischemic stroke in rats

Ting-Lin Yen; Ray-Jade Chen; Thanasekaran Jayakumar; Wan-Jung Lu; Cheng-Ying Hsieh; Ming-Jen Hsu; Chih-Hao Yang; Chao-Chien Chang; Yen-Kuang Lin; Kuan-Hung Lin,; Joen-Rong Sheu

2018-11-01

An antithrombotic strategy by targeting phospholipase D in human platelets

Wan-Jung Lu; Chi-Li Chung; Ray-Jade Chen; Li-Ting Huang; Li-Ming Lien; Chao-Chien Chang; Kuan-Hung Lin; Joen-Rong Sheu

2022-09-01

Artesunate as a glycoprotein VI antagonist for preventing platelet activation and thrombus formation

Wan-Jung Lu; Chung-Hsin Tsai; Ray-Jade Chen; Li-Ting Huang; Ting-Yu Chen; Lih-Chyang Chen; Hsueh-Hsiao Wang; Hsien-Yu Peng; Yu-Yo Sun; Kuan-Hung Lin

2015-12-01

Astaxanthin, a carotenoid, stimulates immune responses by enhancing IFN-γ and IL-2 secretion in primary cultured lymphocytes in vitro and ex vivo

Kuan-Hung Lin; Kao-Chang Lin; Wan-Jung Lu; Philip-Aloysius Thomas; Thanasekaran Jayakumar; Joen-Rong Sheu

2021-11-01

Auraptene, a Monoterpene Coumarin, Inhibits LTA-Induced Inflammatory Mediators via Modulating NF-κB/MAPKs Signaling Pathways

Chih-Hsuan Hsia; Thanasekaran Jayakumar; Wan-Jung Lu; Joen-Rong Sheu; Chih-Wei Hsia; Periyakali Saravana Bhavan; Manjunath Manubolu; Wei-Chieh Huang; Yi Chang

2013-01-01

Brazilin isolated from Caesalpinia sappan L. acts as a novel collagen receptor agonist in human platelets

Yi Chang; Steven Kuan-Hua Huang; Wan-Jung Lu; Chi-Li Chung; Wei-Lin Chen; Shun-Hua Lu; Kuan-Hung Lin; Joen-Rong Sheu

2014-06-01

Characteristics of endogenous γ-aminobutyric acid (GABA) in human platelets: functional studies of a novel collagen glycoprotein VI inhibitor

Kuan-Hung Lin; Wan-Jung Lu; Shwu-Huey Wang; Tsorng-Harn Fong; Duen-Suey Chou; Chao-Chien Chang; Nen-Chung Chang; Yung-Chen Chiang; Shih-Yi Huang; Joen-Rong Sheu

2009-12-01

Comparison of the relative activities of inducing platelet apoptosis stimulated by various platelet-activating agents

Kuan H. Lin; Huai C. Chang; Wan J. Lu; Thanasekaran Jayakumar; Hsiu C. Chou; Tsorng H. Fong; George Hsiao; Joen R. Sheu

2018-06-01

D-Cycloserine Ameliorates Autism-Like Deficits by Removing GluA2-Containing AMPA Receptors in a Valproic Acid-Induced Rat Model

Han-Fang Wu; Po See Chen; Ya-Ting Hsu; Chi-Wei Lee; Tzu-Feng Wang; Yi-Ju Chen; Hui-Ching Lin

2018-09-01

Deep brain stimulation modified autism-like deficits via the serotonin system in a valproic acid-induced rat model

Han-Fang Wu; Yi-Ju Chen; Ming-Chia Chu; Ya-Ting Hsu; Ting-Yi Lu; I-Tuan Chen; Po See Chen; Hui-Ching Lin

2017-08-01

Development of Benzimidazole Derivatives as Novel Anti-platelet Drugs

Wei-Cheng Yao; Lan-Ting Yuan; Wen-Bin Yang; Chih-Hsuan Hsia; Li-Ting Huang; Tzu-Yin Lee; Joen-Rong Sheu; Wan-Jung Lu; Thanasekaran Jayakumar; Ray-Jade Chen

2023-04-01

Different synaptic mechanisms of intermittent and continuous theta-burst stimulations in a severe foot-shock induced and treatment-resistant depression in a rat model

Chi-Wei Lee; Ming-Chia Chu; Han-Fang Wu; Yueh-Jung Chung; Tsung-Han Hsieh; Chieh-Yu Chang; Yen-Cheng Lin; Ting-Yi Lu; Ching-Hsiang Chang; Hsiang Chi; Hsun-Shuo Chang; Yih-Fung Chen; Cheng-Ta Li; Hui-Ching Lin

2019-10-01

Embelin as a novel inhibitor of PKC in the prevention of platelet activation and thrombus formation

Jiun-Yi Li; Ray-Jade Chen; Li-Ting Huang; Tzu-Yin Lee; Wan-Jung Lu; Kuan-Hung Lin

2014-12-01

Ex vivo and in vivo studies of CME-1, a novel polysaccharide purified from the mycelia of Cordyceps sinensis that inhibits human platelet activation by activating adenylate cyclase/cyclic AMP

Wan-Jung Lu; Nen-Chung Chang; Thanasekaran Jayakumar; Jiun-Cheng Liao; Mei-Jiun Lin; Shwu-Huey Wang; Duen-Suey Chou; Philip Aloysius Thomas; Joen-Rong Sheu

2022-07-01

Generational synaptic functions of GABA A receptor β3 subunit deteriorations in an animal model of social deficit

Ming-Chia Chu; Han-Fang Wu; Chi-Wei Lee; Yueh-Jung Chung; Hsiang Chi; Po See Chen; Hui-Ching Lin

2013-05-01

Hinokitiol inhibits platelet activation ex vivo and thrombus formation in vivo

Kuan H. Lin; Jinn R. Kuo; Wan J. Lu; Chi L. Chung; Duen S. Chou; Shih Y. Huang; Hsiu C. Lee; Joen R. Sheu

2014-01-01

Hinokitiol is a novel glycoprotein VI antagonist on human platelets

Wan-Jung Lu; Ming-Ping Wu; Kuan-Hung Lin; Yu-Chen Lin; Hsiu-Chu Chou; Joen-Rong Sheu

2015-08-01

Hinokitiol negatively regulates immune responses through cell cycle arrest in concanavalin A-activated lymphocytes

Chi-Li Chung; Kam-Wing Leung; Wan-Jung Lu; Ting-Lin Yen; Chia-Fu He; Joen-Rong Sheu; Kuan-Hung Lin; Li-Ming Lien

2017-01-01

Honokiol as a specific collagen receptor glycoprotein VI antagonist on human platelets: Functional ex vivo and in vivo studies

Zu-Yin Lee; Chao-Chien Chang; Wan-Jung Lu; Ting-Lin Yen; Kuan-Hung Lin; Pitchairaj Geraldine; Jiun-Yi Li; Joen-Rong Sheu

2019-02-01

In Vivo Real-Time Discrimination Among Glioma, Infiltration Zone, and Normal Brain Tissue via Autofluorescence Technology

Kai-Ting Chang; Yu-Yi Lin; Ya-Yu Lin; Yi-Lo Lin; Henrich Cheng; Yin Chang; Ming-Chao Huang

2020-05-01

Increased GABAergic inhibitory function against ischemic long-term potentiation in the CA1 region of the hippocampus

Ming-Chia Chu; Jing-Ying Lee; Hung-Fu Lee; Kai-Wen Chu; Han-Fang Wu; Chi-Wei Lee; Chia-Hsien Lin; Chih-Wei Tang; Hui-Ching Lin

2021-09-01

Influence of vincristine, clinically used in cancer therapy and immune thrombocytopenia, on the function of human platelets

Li-Ming Lien; Wan-Jung Lu; Kuan-Hung Lin; Ling-Hsuan Kang; Ting-Yu Chen; Bo-Jung Lin; Hsuan Chen; Yao-Chou Tsai; Ray-Jade Chen; Joen-Rong Sheu

2015-03-01

Inhibitory mechanisms of CME-1, a novel polysaccharide from the mycelia of Cordyceps sinensis, in platelet activation

Yi Chang; Wen-Hsien Hsu; Wan-Jung Lu; Thanasekaran Jayakumar; Jiun-Cheng Liao; Mei-Jiun Lin; Shwu-Huey Wang; Pitchairaj Geraldine; Kuan-Hung Lin; Joen-Rong Sheu

2019-07-01

Ketamine ameliorates severe traumatic event-induced antidepressant-resistant depression in a rat model through ERK activation

Chi-Wei Lee; Yi-Ju Chen; Han-Fang Wu; Yueh-Jung Chung; Yi-Chao Lee; Cheng-Ta Li; Hui-Ching Lin

2018-08-01

Licochalcone A attenuates glioma cell growth in vitro and in vivo through cell cycle arrest

Wan-Jung Lu; Gong-Jhe Wu; Ray-Jade Chen; Chao-Chien Chang; Li-Ming Lien; Ching-Chuan Chiu; Mei-Fang Tseng; Li-Ting Huang; Kuan-Hung Lin

2017-07-01

Licochalcone A prevents platelet activation and thrombus formation through the inhibition of PLCγ2-PKC, Akt, and MAPK pathways

Li-Ming Lien; Kuan-Hung Lin; Li-Ting Huang; Mei-Fang Tseng; Hou-Chang Chiu; Ray-Jade Chen; Wan-Jung Lu

2020-12-01

Magnolol, a novel antagonist of thrombin and PAR-1, inhibits thrombin-induced connective tissue growth factor (CTGF) expression in vascular smooth muscle cells and ameliorate pathogenesis of restenosis in rats

Wen-Chin Ko; Chia-Ti Tsai; Kai-Cheng Hsu; Yu-Che Cheng; Tony Eight Lin; Yi-Ling Chen; Chuang-Ye Hong; Wan-Jung Lu; Chun-Ming Shih; Ting-Lin Yen

2021-01-01

Mechanism of intermittent theta-burst stimulation in synaptic pathology in the prefrontal cortex in an antidepressant-resistant depression rat model

Chi-Wei Lee; Han-Fang Wu; Ming-Chia Chu; Yueh-Jung Chung; Wei-Chang Mao; Cheng-Ta Li; Hui-Ching Lin

2013-11-01

Mechanisms of andrographolide-induced platelet apoptosis in human platelets: regulatory roles of the extrinsic apoptotic pathway

Li-Ming Lien; Cheng-Chen Su; Wen-Hsien Hsu; Wan-Jung Lu; Chi-Li Chung; Ting-Lin Yen; Hou-Chang Chiu; Joen-Rong Sheu; Kuan-Hung Lin

2022-07-01

Metformin Serves as a Novel Drug Treatment for Arterial Thrombosis: Inhibitory Mechanisms on Collagen-Induced Human Platelet Activation

Yi Chang; Wei Chieh Huang; Chia Yuan Hsu; Chih Wei Hsia; Thanasekaran Jayakumar; Cheng Ying Hsieh; Wan Jung Lu; Chao Chien Chang

2019-07-01

MR imaging central thalamic deep brain stimulation restored autistic-like social deficits in the rat

Lin, Ting-Chun; Lo, Yu-Chun; Lin, Hui-Ching; Li, Ssu-Ju; Lin, Sheng-Huang; Wu, Han-Fang; Chu, Ming-Chia; Lee, Chi-Wei; Lin, I-Cheng; Chang, Ching-Wen; Liu, Yin-Chieh; Chen, Ting-Chieh; Lin, Yu-Ju; Shih, Yen-Yu Ian; Chen, You-Yin

2014-08-01

Multidrug resistance protein 4 (MRP4/ABCC4) regulates thrombus formation in vitro and in vivo

Li-Ming Lien, Zhih-Cherng Chen, Chi-Li Chung, Ting-Lin Yen, Hou-Chang Chiu, Duen-Suey Chou, Shih-Yi Huang, Joen-Rong Sheu, Wan-Jung Lu, Kuan-Hung Lin.

2015-12-01

n-3 Polyunsaturated fatty acids ameliorate cognitive age-related impairments and depressive behaviour in unchallenged aged prediabetic rats

Yu-Ru Guo, Yi-Hao Hsu, An Liang, Wan-Jung Lu, Chi-Hao Wu, Hsiu-Chuan Lee, Shih-Yi Huang.

2012-02-01

Neuroprotective effects of xanthohumol, a prenylated flavonoid from hops (humulus lupulus), in ischemic stroke of rats

Ting-Lin Yen, Chung-King Hsu, Wan-Jung Lu, Cheng-Ying Hsieh, George Hsiao, Duen-Suey Chou, Gong-Jhe Wu, Joen-Rong Sheu.

2019-03-01

New therapeutic strategy of hinokitiol in haemorrhagic shock-induced liver injury

Lu, Wan-Jung; Lin, Kuan-Hung; Tseng, Mei-Fang; Yuan, Kuo-Ching; Huang, Hung-Chang; Sheu, Joen-Rong; Chen, Ray-Jade

2017-01-01

Nobiletin, a citrus flavonoid, activates vasodilator-stimulated phosphoprotein in human platelets through non-cyclic nucleotide-related mechanisms

Jayakumar, Thanasekaran; Lin, Kao-Chang; Lu, Wan-Jung; Lin, Chia-Ying; Pitchairaj, Geraldine; Li, Jiun-Yi; Sheu, Joen-Rong

2016-02-01

Nobiletin, a polymethoxylated flavone, inhibits glioma cell growth and migration via arresting cell cycle and suppressing MAPK and Akt pathways

Lien, Li-Ming; Wang, Meng-Jiy; Chen, Ray-Jade; Chiu, Hou-Chang; Wu, Jia-Lun; 8, Ming-Yi Shen; Chou, Duen-Suey; Sheu, Joen-Rong; Lin, Kuan-Hung; Lu, Wan-Jung

2018-01-01

Norcantharidin, a clinical used chemotherapeutic agent, acts as a powerful inhibitor by interfering with fibrinogen-integrin αIIbβ3 binding in human platelets

Hsia, Chih-Hsuan; Lu, Wan-Jung; Lin, Kuan-Hung; Chou, Duen-Suey; Geraldine, Pitchairaj; Jayakuma, Thanasekaran; Chang, Nen-Chung; Sheu, Joen-Rong

2013-06-01

A novel antithrombotic effect of sulforaphane via activation of platelet adenylate cyclase: ex vivo and in vivo studies

Thanasekaran Jayakumar, Wei-Fan Chen, Wan-Jung Lu, Duen-Suey Chou, George Hsiao, Chung-Yi Hsu, Joen-Rong Sheu, Cheng-Ying Hsieh

2013-09-01

A novel bioactivity of andrographolide from Andrographis paniculata on cerebral ischemia/reperfusion-induced brain injury through induction of cerebral endothelial cell apoptosis

Ting-Lin Yen, Wen-Hsien Hsu, Steven Kuan-Hua Huang, Wan-Jung Lu, Chao-Chien Chang, Li-Ming Lien, George Hsiao, Joen-Rong Sheu & Kuan-Hung Lin

2024-10-01

A Novel Device for Vergence Exercises: Testing Automatic Dual Rotational Risley Prisms on Asymptomatic Adults and Patients with Convergence Insufficiency

Chen, Ya-Yu; Hu, Yun-Shao; Huang, Shuan-Yu; Tsai, Tzu-Hsun

2021-10-01

A novel naphthalimide derivative reduces platelet activation and thrombus formation via suppressing GPVI

Shih, Tzenge-Lien; Lin, Kuan-Hung; Chen, Ray-Jade; Chen, Ting-Yu; Kao, Wei-Ting; Liu, Jen-Wei; Wang, Hsueh-Hsiao; Peng, Hsien-Yu; Sun, Yu-Yo; Lu, Wan-Jung

2011-12-01

A novel role of andrographolide, an NF-kappa B inhibitor, on inhibition of platelet activation: the pivotal mechanisms of endothelial nitric oxide synthase/cyclic GMP

Wan-Jung Lu, Jie-Jen Lee, Duen-Suey Chou, Thanasekaran Jayakumar, Tsorng-Han Fong, George Hsiao & Joen-Rong Sheu

2011-12-01

A novel role of sesamol in inhibiting NF-κB-mediated signaling in platelet activation

Chao-Chien Chang, Wan-Jung Lu, Eng-Thiam Ong, Cheng-Wen Chiang, Song-Chow Lin, Shih-Yi Huang & Joen-Rong Sheu

2017-08-01

A novel ruthenium (II)-derived organometallic compound, TQ-6, potently inhibits platelet aggregation: Ex vivo and in vivo studies

Hsia, Chih-Hsuan; Velusamy, Marappan; Sheu, Joen-Rong; Khamrang, Themmila; Jayakumar, Thanasekaran; Lu, Wan-Jung; Lin, Kuan-Hung; Chang, Chao-Chien

2016-02-01

Novel synthetic benzimidazole-derived oligosaccharide, M3BIM, prevents ex vivo platelet aggregation and in vivo thromboembolism

Ting-Lin Yen, Ming-Ping Wu, Chi-Li Chung, Wen-Bin Yang, Thanasekaran Jayakumar, Pitchairaj Geraldine, Chih-Ming Chou, Chia-Yau Chang, Wan-Jung Lu, Joen-Rong Sheu

2023-05-01

Paclitaxel exerts antiplatelet and antithrombotic activities: Additional benefit from use of paclitaxel-coated balloons and -eluting stents in coronary revascularization and prevention of in-stent restenosis

Lin, Kuan-Hung; Li, Jiun-Yi; Chen, Ray-Jade; Chen, Ting-Yu; Hsu, Shao-Hsuan; Wang, Hsueh-Hsiao; Peng, Hsien-Yu; Sun, Yu-Yo; Lu, Wan-Jung

2020-09-01

Phospholipase D1 and D2 Synergistically Regulate Thrombus Formation

Lien, Li-Ming; Lu, Wan-Jung; Chen, Ting-Yu; Lee, Tzu-Yin; Wang, Hsueh-Hsiao; Peng, Hsien-Yu; Chen, Ray-Jade; Lin, Kuan-Hung

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