A novel naphthalimide derivative reduces platelet activation and thrombus formation via suppressing GPVI

請使用永久網址來引用或連結此文件: http://140.112.115.32:8080/ir/handle/987654321/2787

題名:	A novel naphthalimide derivative reduces platelet activation and thrombus formation via suppressing GPVI
作者:	Shih, Tzenge-Lien;Lin, Kuan-Hung;Chen, Ray-Jade;Chen, Ting-Yu;Kao, Wei-Ting;Liu, Jen-Wei;Wang, Hsueh-Hsiao;Peng, Hsien-Yu;Sun, Yu-Yo;Lu, Wan-Jung
貢獻者:	視光學系
日期:	2021-10-01
上傳時間:	2025-08-11 14:43:50 (UTC+8)
摘要:	Naphthalimide derivatives have multiple biological activities, including antitumour and anti-inflammatory activities. We previously synthesized several naphthalimide derivatives; of them, compound 5 was found to exert the strongest inhibitory effect on human DNA topoisomerase II activity. However, the effects of naphthalimide derivatives on platelet activation have not yet been investigated. Therefore, the mechanism underlying the antiplatelet activity of compound 5 was determined in this study. The data revealed that compound 5 (5–10 μM) inhibited collagen- and convulxin- but not thrombin- or U46619-mediated platelet aggregation, suggesting that compound 5 is more sensitive to the inhibition of glycoprotein VI (GPVI) signalling. Indeed, compound 5 could inhibit the phosphorylation of signalling molecules downstream of GPVI, followed by the inhibition of calcium mobilization, granule release and GPIIb/IIIa activation. Moreover, compound 5 prevented pulmonary embolism and prolonged the occlusion time, but tended to prolong the bleeding time, indicating that it can prevent thrombus formation but may increase bleeding risk. This study is the first to demonstrate that the naphthalimide derivative compound 5 exerts antiplatelet and antithrombotic effects. Future studies should modify compound 5 to synthesize more potent and efficient antiplatelet agents while minimizing bleeding risk, which may offer a therapeutic potential for cardiovascular diseases.
關聯:	Journal of Cellular and Molecular Medicine, 25(19), 9434-9446. https://doi.org/https://doi.org/10.1111/jcmm.16886
顯示於類別:	[視光學系] 期刊論文

文件中的檔案:

檔案	大小	格式	瀏覽次數
index.html	0Kb	HTML	2	檢視/開啟

在MMUIR中所有的資料項目都受到原著作權保護.

資料載入中.....