Licochalcone A attenuates glioma cell growth in vitro and in vivo through cell cycle arrest

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题名:	Licochalcone A attenuates glioma cell growth in vitro and in vivo through cell cycle arrest
作者:	Lu, Wan Jung;Wu, Gong Jhe;Chen, Ray Jade;Chang, Chao Chien;Lien, Li Ming;Chiu, Ching Chuan;Tseng, Mei Fang;Huang, Li Ting;Lin, Kuan Hung
贡献者:	視光學系
日期:	2018-08-01
上传时间:	2025-08-11 14:44:08 (UTC+8)
摘要:	Licochalcone A (LA), an active ingredient of licorice, has multiple biological activities, including antioxidative and anti-inflammatory activities. Although LA exerts antitumor effects in various cancer cells, its role in gliomas remains unclear. Therefore, this study determined whether LA inhibits glioma cell growth in vitro and in vivo. The present data revealed that LA effectively inhibited the growth of U87 glioma cells by inducing cell cycle arrest in the G0/G1 and G2/M phases; cell cycle arrest was attributed to the LA-mediated reduction of mRNA and protein levels of cyclins and cyclin-dependent kinases. Moreover, subcutaneous (flank) and orthotopic (brain) tumor models were used to determine the role of LA in gliomas. LA significantly alleviated tumor growth in both models. These findings indicate that LA exerts antitumor effects in gliomas in vitro and in vivo and that it is a potential agent for treating glioblastoma multiforme.
關聯:	Food & Function, 9, 4500-4507. https://doi.org/10.1039/c8fo00728d
显示于类别:	[視光學系] 期刊論文

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