Magnolol, a novel antagonist of thrombin and PAR-1, inhibits thrombin-induced connective tissue growth factor (CTGF) expression in vascular smooth muscle cells and ameliorate pathogenesis of restenosis in rats

請使用永久網址來引用或連結此文件: http://140.112.115.32:8080/ir/handle/987654321/2805

題名:	Magnolol, a novel antagonist of thrombin and PAR-1, inhibits thrombin-induced connective tissue growth factor (CTGF) expression in vascular smooth muscle cells and ameliorate pathogenesis of restenosis in rats
作者:	Wen-Chin Ko;Chia-Ti Tsai;Kai-Cheng Hsu;Yu-Che Cheng;Tony Eight Lin;Yi-Ling Chen;Chuang-Ye Hong;Wan-Jung Lu;Chun-Ming Shih;Ting-Lin Yen
貢獻者:	視光學系
關鍵詞:	CTGF;Magnolol;PAR-1;Restenosis;Thrombin inhibitor
日期:	2020-12-01
上傳時間:	2025-08-11 14:44:11 (UTC+8)
摘要:	Restenosis and destructive vascular remodeling are the main reasons for treatment failure in patients undergoing percutaneous coronary intervention (PCI). In this study, we explored the efficacy of magnolol (a traditional Chinese medicine) in the treatment of restenosis. The results of this study showed that the activities of thrombin and PAR-1 (protease-activated receptor 1) were significantly decreased by the treatment of magnolol. Based on protein docking analysis, magnolol exhibits its potential to bind to the PAR-1 active site. In addition, thrombin-induced connective tissue growth factor (CTGF) expression and the upstream of CTGF such as JNK-1 (but not JNK-2), c-Jun, and AP-1 were distinctly inhibited by magnolol (50 µM) in vascular smooth muscle cells (VSMC). For the functional assay, magnolol (50 µM) significantly inhibited the migration of VSMC, and rats treated with magnolol (13 mg/kg/day) after balloon angioplasty has observed a significant reduction in the formation of common arterial neointima. In conclusion, we identified a novel mechanism by which magnolol acts as the thrombin activity inhibitor and may be the PAR-1 antagonist. In accordance with these functions, magnolol could decrease thrombin-induced CTGF expression in VSMCs via PAR-1/JNK-1/AP-1 signaling.
關聯:	Applied Sciences-Basel, 10(23), 8729. https://doi.org/10.3390/app10238729
顯示於類別:	[視光學系] 期刊論文

文件中的檔案:

檔案	大小	格式	瀏覽次數
index.html	0Kb	HTML	19	檢視/開啟

在MMUIR中所有的資料項目都受到原著作權保護.

資料載入中.....