Phospholipase D1 and D2 Synergistically Regulate Thrombus Formation

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题名:	Phospholipase D1 and D2 Synergistically Regulate Thrombus Formation
作者:	Lien, Li-Ming;Lu, Wan-Jung;Chen, Ting-Yu;Lee, Tzu-Yin;Wang, Hsueh-Hsiao;Peng, Hsien-Yu;Chen, Ray-Jade;Lin, Kuan-Hung
贡献者:	視光學系
关键词:	middle cerebral artery occlusion;phospholipase D;platelet;thrombosis
日期:	2020-09-01
上传时间:	2025-08-11 14:44:21 (UTC+8)
摘要:	Previously, we reported that phospholipase D1 (PLD1) and PLD2 inhibition by selective PLD1 and PLD2 inhibitors could prevent platelet aggregation in humans, but not in mice. Moreover, only the PLD1 inhibitor, but not PLD2 inhibitor, could effectively prevent thrombus formation in mice, indicating that PLD might play different roles in platelet function in humans and mice. Although PLD1 and PLD2 were reported to be implicated in thrombotic events, the role of PLD in mice remains not completely clear. Here, we investigated the role of PLD1 and PLD2 in acute pulmonary thrombosis and transient middle cerebral artery occlusion-induced brain injury in mice. The data revealed that inhibition of PLD1, but not of PLD2, could partially prevent pulmonary thrombosis-induced death. Moreover, concurrent PLD1 and PLD2 inhibition could considerably increase survival rate. Likewise, inhibition of PLD1, but not PLD2, partially improved ischemic stroke and concurrent inhibition of PLD1, and PLD2 exhibited a relatively better protection against ischemic stroke, as evidenced by the infarct size, brain edema, modified neurological severity score, rotarod test, and the open field test. In conclusion, PLD1 might play a more important role than PLD2, and both PLD1 and PLD2 could act synergistically or have partially redundant functions in regulating thrombosis-relevant events.
關聯:	International Journal of Molecular Sciences, 21. https://doi.org/10.3390/ijms21186954
显示于类别:	[視光學系] 期刊論文

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